The animals were of different sizes and different motions and to yoke them together would be an unequal yoking that would cause discomfort to each and interfere with the effective work of both...

"Be ye not unequally yoked together with unbelievers" (2 Cor. 6:14).

'... a typical intimation of God's disapproval of all partnerships between men (and of course women) of such difference of principle as prevails between those who fear God and those who fear Him not.

"Can two walk together except they be agreed?" (Amos 3:3).

A man of the world and a man of God could not work in common, as regards principles of action and aims of life, without either the man of the world giving in to the man of God, which is improbable; or the man of God becoming corrupted by the man of the world, which is more likely.

The principle applies in all connections where the will of one man is put in the power of another. The friends of God are "not of the world", They are commanded to "come out from among them, and be separate". There are matters in which all are tied together in a common interest, such as the passengers in the same ship or the residents in the same village or town.

Saints must live with, and in many matters co-operate with sinners, so long as God tolerates the sinners; but as regards the main purposes and friendships of life, it is safe and indeed (in the case of true saints) an inevitable rule, to refuse putting the neck in the same yoke with those who are unbelieving or unloving or disobedient towards God'.